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Article

The role of ABCA1 gene sequence variants on risk of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Lupton Michelle K, Proitsi Petroula, Lin Kuang, Hamilton Gillian, Daniilidou Makrina, Tsolaki Magda, Powell John F

Abstract excerpt

The ATP-binding cassette, sub-family A, member 1 gene (ABCA1) is a candidate risk gene for late onset Alzheimer's disease (LOAD) as a consequence of its role in cholesterol transport and metabolism, which is implicated in LOAD risk. ABCA1 has been shown in mouse models to enable the clearance of amyloid-β peptide from the brain, through its role in the lipidation of apolipoprotein (APOE). Although recent large...

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Source

Identifiers

PMID: 24081377
DOI: 10.3233/JAD-131121

Genes

ABCA1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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