Article
Approaches to Timescale Choice in Cognitive Aging Research and Potential Implications for Estimated Exposure Effects: Coordinated Analyses in 10 Cohorts of Older Adults.
Epidemiology (Cambridge, Mass.) - 1 Jul 2025
Hayes-Larson Eleanor, Andrews Ryan M, Kezios Katrina L, Bercu Ariane, Rouanet Anaïs, Helmer Catherine, Crane Paul K, Gibbons Laura E, Klinedinst Brandon S, McEvoy Linda K, Nichols Emma, Weuve Jennifer, Rajan Kumar B, Hwang Phillip H, Mez Jesse, Farina Mateo, Shaw Crystal, Sims Kendra D, Therneau Terry, Petersen Ronald C, Bouteloup Vincent, Gross Alden L, Albert Marilyn, Morris John C, Masters Colin L, Resnick Susan M, Maruff Paul, Manly Jennifer J, Turney Indira C, Vonk Jet M J, Avila-Rieger Justina, Weigand Alexandra, Chen Ruijia, Wang Jingxuan, Proust-Lima Cécile, Mayeda Elizabeth Rose
Abstract excerpt
BACKGROUND: Cognitive change is an important factor in understanding dementia. Estimating effects of exposures on cognitive change requires choosing an analytical timescale, typically time on study or current age. There is limited consensus regarding timescale choice in epidemiologic cognitive aging research. METHODS: Using a coordinated analytic approach in 10 cohorts of older adults, we evaluated whether...
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