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Article

The countdown paradox: time-varying analysis of biomarker-clock age and symptom onset

2026-06-29

Abstract excerpt

Research focused on Alzheimer’s disease (AD) ‘biomarker clocks’ seeks to identify ages at which AD pathological landmarks occur (e.g., initiation of amyloid accumulation) and are meaningfully related to disease outcomes (e.g., symptom onset). However, the statistical approach for assessing the association between age at biomarker-clock event and remaining time to clinical symptom onset can create a structural arti...

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Literature Corpus work
ae08b0b5-778e-550b-96a1-cf148c21b70b
DOI
10.64898/2026.06.19.26355994
Open publication

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The countdown paradox: time-varying analysis of biomarker-clock age and symptom onsetDOI 10.64898/2026.06.19.26355994
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