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Naturally occurring pre-S mutations promote occult HBV infection by affecting pre-S2/S promoter activity.

Antiviral research - 1 Dec 2022

Sun Huizhen, Chang Le, Yan Ying, Ji Huimin, Jiang Xinyi, Song Shi, Xiao Yingzi, Lu Zhuoqun, Wang Lunan

Abstract excerpt

Occult hepatitis B virus (HBV) infection (OBI) has non-negligible clinical significance, but the mechanism of its occurrence remains unclear. Growing evidence suggests that mutations in the pre-S region of HBV genome may be associated with the occurrence of OBI. However, the role of pre-S mutations in OBI and its molecular mechanism was not fully understand. Here, the pre-S sequences from 307 OBI blood donors and...

Topics

Humans
Hepatitis B virus
Hepatitis B Surface Antigens
Hepatitis B
Hepatitis B, Chronic
Genotype
Mutation
DNA, Viral

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36257516
DOI: 10.1016/j.antiviral.2022.105448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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