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Article

Frequency of HBsAg variants in occult hepatitis B virus infected patients and detection by ARCHITECT HBsAg quantitative.

Frontiers in cellular and infection microbiology - 1 Jan 2024

He Chengshan, Liu Yang, Jiang Xiudi, Xu Zheng, Xiang Zhouhong, Lu Zhicheng

Abstract excerpt

Objective: To analyze the amino acid substitution caused by mutations in the major hydrophilic region (MHR) of the S-region genes in the serum samples of occult hepatitis B virus infection (OBI), and to explore the reasons for the missed detection of HBsAg. Method: The full-length gene of the S-region in hepatitis B virus(HBV) in the chronic hepatitis B virus(CHB)(10 samples) and OBI groups(42 samples) was...

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Identifiers

PMID: 38766475
DOI: 10.3389/fcimb.2024.1368473
PMCID: PMC11099262

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