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Cellular Discrepancy of Platinum Complexes in Interfering with Mitochondrial DNA

24 Jan 2025

Abstract excerpt

Mitochondria are associated with cellular energy metabolism, proliferation, and mode of death. Damage to mitochondrial DNA (mtDNA) greatly affects mitochondrial function by interfering with energy production and the signaling pathway. Monofunctional trinuclear platinum complex MTPC demonstrates different actions on the mtDNA of cancerous and normal cells. It severely impairs the integrity and function of...

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PMID: 40161961
DOI: 10.1021/acscentsci.4c01941

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