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Zinc amino acid chelate and the Aryl Hydrocarbon Receptor (AHR) cooperate in improving the barrier function of a Caco-2 cell intestinal epithelium

27 Mar 2025

Abstract excerpt

• Activation of the aryl hydrocarbon receptor (AHR) with 6-formylindolo(3,2-b)carbazole (FICZ), enhances zinc-induced tightness of a Caco-2 intestinal cell epithelium. • FICZ improves the ability of zinc to stimulate expression of tight junction proteins at the mRNA and protein levels. • Lysine and glutamic acid chelate of Zn is efficacious in reducing permeability of the Caco-2 cell epithelium in the presence of...

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PMID: 40154643
DOI: 10.1016/j.jnutbio.2025.109909

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