Article
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit.
Nature neuroscience - 3 Jul 2011
Nozaki Chihiro, Vergnano Angela Maria, Filliol Dominique, Ouagazzal Abdel-Mouttalib, Le Goff Anne, Carvalho Stéphanie, Reiss David, Gaveriaux-Ruff Claire, Neyton Jacques, Paoletti Pierre, Kieffer Brigitte L
Abstract excerpt
Zinc is abundant in the central nervous system and regulates pain, but the underlying mechanisms are unknown. In vitro studies have shown that extracellular zinc modulates a plethora of signaling membrane proteins, including NMDA receptors containing the NR2A subunit, which display exquisite zinc sensitivity. We created NR2A-H128S knock-in mice to investigate whether Zn2+-NR2A interaction influences pain control....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.