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Article

Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat.

Gastroenterology - 1 Mar 2009

Taccioli Cristian, Wan Shao-Gui, Liu Chang-Gong, Alder Hansjuerg, Volinia Stefano, Farber John L, Croce Carlo M, Fong Louise Y Y

Abstract excerpt

BACKGROUND & AIMS: Zinc deficiency is implicated in the pathogenesis of human esophageal cancer. In the rat esophagus, it induces cell proliferation, modulates genetic expression, and enhances carcinogenesis. Zinc-replenishment reverses proliferation and inhibits carcinogenesis. The zinc-deficient rat model allows the identification of biological differences affected by zinc during early esophageal...

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Identifiers

PMID: 19111725
DOI: 10.1053/j.gastro.2008.11.039
PMCID: PMC2650087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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