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Metallothionein 1G and Zinc Sensitize Human Colorectal Cancer Cells to Chemotherapy

15 Mar 2014

Abstract excerpt

Metallothioneins (MT) are a family of low molecular weight proteins that are silenced during colorectal cancer progression, mainly through epigenetic mechanisms, and this loss is associated with poor survival. In this article, we show that overexpression of the MT1G isoform sensitizes colorectal cell lines to the chemotherapeutic agents oxaliplatin (OXA) and 5-fluorouracil (5-FU), in part through enhancing p53...

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PMID: 24634414
DOI: 10.1158/1535-7163.mct-13-0944

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