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Aryl hydrocarbon receptor utilises cellular zinc signals to maintain the gut epithelial barrier

2022-11-04

Abstract excerpt

Both zinc and plant-derived ligands of the aryl hydrocarbon receptor (AHR) are dietary components which regulate intestinal epithelial barrier function and protect against Inflammatory Bowel Disease (IBD) 1,2 . Here, we explore whether zinc and AHR pathway are linked using a mouse IBD model with follow-on studies on human and mouse ileum organoids. Our data demonstrate that AHR regulates cellular zinc uptake, and...

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Literature Corpus work
0acee28b-c9d1-54ac-9a76-4b5aa88fd455
DOI
10.1101/2022.11.03.515052
Open publication

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Aryl hydrocarbon receptor utilises cellular zinc signals to maintain the gut epithelial barrierDOI 10.1101/2022.11.03.515052
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