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Article

SIRT7 facilitates endometrial cancer progression by regulating PTEN stability in an estrogen-dependent manner

27 Mar 2025

Abstract excerpt

The prognosis of metastatic endometrial carcinoma (EC), one of the most common gynecological malignancies worldwide, remains poor, and the underlying driver of metastases is poorly understood. Dysregulation in estrogen-related signaling and inactivation of tumor suppressor PTEN are two essential risk factors of EC. However, whether and how they are interconnected during EC development remains unclear. Here, we...

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PMID: 40148340
DOI: 10.1038/s41467-025-58317-0

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