Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WTAP/IGF2BP3 mediated m6A modification of the EGR1/PTEN axis regulates the malignant phenotypes of endometrial cancer stem cells.

Journal of experimental & clinical cancer research : CR - 23 Jul 2024

Wang Bo, Wang Yuting, Wang Wantong, Wang Zihao, Zhang Yunzheng, Pan Xin, Wen Xin, Leng Hongrui, Guo Jing, Ma Xiao-Xin

Abstract excerpt

Endometrial cancer (EC) stem cells (ECSCs) are pivotal in the oncogenesis, metastasis, immune escape, chemoresistance, and recurrence of EC. However, the specific mechanism of stem cell maintenance in EC cells (ECCs) has not been clarified. We found that WTAP and m6A levels decreased in both EC and ECSCs, and that knocking down WTAP promoted ECCs and ECSCs properties, including proliferation, invasion, migration,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Adenosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Early Growth Response Protein 1

Share to Endometrial Neoplasms

Share to Gene Expression Regulation, Neoplastic

Share to Neoplastic Stem Cells

Share to PTEN Phosphohydrolase

Share to RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39044249
DOI: 10.1186/s13046-024-03120-w
PMCID: PMC11264439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WTAP/IGF2BP3 mediated m6A modification of the EGR1/PTEN axis regulates the malignant phenotypes of endometrial cancer stem cells.PMID 39044249Read ↗

Landscape of Endometrial Cancer: Molecular Mechanisms, Biomarkers, and Target TherapySemantic proximity Read ↗

PTEN overexpression and nuclear beta-catenin stabilization promote morular differentiation through induction of epithelial-mesenchymal transition and cancer stem cell-like properties in endometrial carcinomaSemantic proximity Read ↗

Genomic and Transcriptomic Characterization Revealed the High Sensitivity of Targeted Therapy and Immunotherapy in a Subset of Endometrial Stromal SarcomaSemantic proximity Read ↗

A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer.Semantic proximity Read ↗

Prognostic Analysis of PTEN Mutation in Endometrial CarcinomaSemantic proximity Read ↗

Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axisSemantic proximity Read ↗

Epithelial to Mesenchymal Transition and Cell Biology of Molecular Regulation in Endometrial CarcinogenesisSemantic proximity Read ↗

Identification of a distinct AREG+ cell population that promotes the progression, recurrence, and metastasis of endometrioid endometrial cancer at single-cell resolutionSemantic proximity Read ↗

Significance of PTEN Mutational Status Associated Gene Signature in the Progression and Prognosis of Endometrial CarcinomaSemantic proximity Read ↗

Significance of a PTEN Mutational Status-Associated Gene Signature in the Progression and Prognosis of Endometrial Carcinoma.Semantic proximity Read ↗

Establishing a Prognostic Signature Based on Epithelial–Mesenchymal Transition-Related Genes for Endometrial Cancer PatientsSemantic proximity Read ↗

LncRNA MONC Suppresses the Malignant Phenotype of Endometrial Cancer Stem Cells by Regulating the MiR-636/GLCE AxisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.