Article

A Human PBMC-Based New Approach Method Reveals PFAS-Driven T-Cell Proliferation and Immune Dysregulation

2026-05-12

Abstract excerpt

<title>Abstract</title> <p> Immunotoxicity has emerged as a key health concern for per- and polyfluoroalkyl substances (PFAS), with animal studies showing reduced T-dependent antibody responses (TDAR) and epidemiological studies reporting decreased vaccine antibody titers. Notably, immunotoxicity is considered one of the most sensitive endpoints for PFAS exposure and has been used to inform regulatory guidance a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1fce7701-0405-56bb-b3bf-7fcfdb5ff302
DOI: 10.21203/rs.3.rs-9484386/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Human PBMC-Based New Approach Method Reveals PFAS-Driven T-Cell Proliferation and Immune DysregulationDOI 10.21203/rs.3.rs-9484386/v1Read

Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 VaccineesSemantic proximity Read

An ex vivo human model for safety assessment of immunotoxicity of engineered nanomaterialsSemantic proximity Read

Chemical exposures affect innate immune response to SARS-CoV-2Semantic proximity Read

Potential effects of PFAS exposure on trained immunity: From mechanisms to health risksSemantic proximity Read

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterizationSemantic proximity Read

Integrative omics analyses uncover the mechanism underlying the immunotoxicity of perfluorooctanesulfonate in human lymphocytesSemantic proximity Read

Cell-Type specific toxicity of heptadecafluorooctanesulfonic acid (PFOS), pentadecafluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA): mechanistic insights into oral exposure pathwaysSemantic proximity Read

Statistical Methodology for Qualification of a Non-Clinical Risk Assessment Peptide:T Cell Proliferation Assay to Support Decision MakingSemantic proximity Read

Per- and polyfluoroalkyl substances (PFAS) Regulatory Frameworks, Sources, Occurrence, Fate, and Exposure: Trend, Concern, and ImplicationSemantic proximity Read

Exposure to PFOA and GenX elicits cell type-specific impacts on p53 and TGF-β signaling pathwaysSemantic proximity Read

High-throughput transcriptomics and benchmark concentration modeling for potency ranking of per- and polyfluoroalkyl substances (PFAS) in exposed human liver cell spheroidsSemantic proximity Read

Integrating high-throughput phenotypic profiling and transcriptomic analyses to predict the hepatosteatosis effects induced by per- and polyfluoroalkyl substances.Semantic proximity Read