Article

No Evidence of Direct Activation of Human Neutrophil Responses by Multivalent Prefusion Trimeric SARS-CoV-2 Spike Protein <i>ex vivo</i>

2025-05-08

Abstract excerpt

The SARS-CoV-2 Spike (S) protein is essential for viral entry and serves as the primary immunogen in most COVID-19 vaccines. While its role in adaptive immunity is well defined, its potential to contribute directly to innate immune activation and remains incompletely understood. Neutrophils, in particular, are prominent effectors in COVID-19 severity, yet how they respond directly to the S protein presented in a m...

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Literature Corpus work: e7b5f6ff-3203-5941-b1e1-5341b470bace
DOI: 10.1101/2025.05.08.652856

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