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Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation

2025-06-10

Abstract excerpt

<h4>Background and Purpose</h4> Rare but serious adverse events (AEs) associated with mRNA-lipid nanoparticle (LNP) COVID-19 vaccines, such as Comirnaty and Spikevax, include anaphylaxis and acute multiorgan inflammatory syndrome. The mechanisms of these acute innate immune responses remain poorly understood. This study aimed to investigate these effects using an amplified porcine model. <h4>Experimental Approach...

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Literature Corpus work
49f2c304-c4ab-52f9-9f08-be3f3acede19
DOI
10.1101/2025.06.07.658379
Open publication

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Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulationDOI 10.1101/2025.06.07.658379
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