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Development of a General Purpose Targeted LC-MS Method for Accurate Quantification of the SARS-CoV-2 Spike Protein Expression

2025-03-12

Abstract excerpt

The COVID-19 pandemic has catalyzed interest in immuno-multiple reaction monitoring (immuno-MRM) methods, with the detection of peptides unique to the nucleocapsid protein in nasopharyngeal swabs. While current applications predominantly focus on disease biomarkers, the pandemic has unveiled new opportunities, namely for the quantification of antigen expression following mRNA vaccination. Here, we present an optim...

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Literature Corpus work
377475b6-27c6-5d28-a226-32bb81b0bfb6
DOI
10.1101/2025.03.11.642564
Open publication

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Development of a General Purpose Targeted LC-MS Method for Accurate Quantification of the SARS-CoV-2 Spike Protein ExpressionDOI 10.1101/2025.03.11.642564
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