Article
Role of glycosylation mutations at the N-terminal domain of SARS-CoV-2 XEC variant in immune evasion, cell-cell fusion, and spike stability.
Journal of virology - 15 Apr 2025
Li Pei, Faraone Julia N, Hsu Cheng Chih, Chamblee Michelle, Liu Yajie, Zheng Yi-Min, Xu Yan, Carlin Claire, Horowitz Jeffrey C, Mallampalli Rama K, Saif Linda J, Oltz Eugene M, Jones Daniel, Li Jianrong, Gumina Richard J, Bednash Joseph S, Xu Kai, Liu Shan-Lu
Abstract excerpt
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, producing new variants that drive global coronavirus disease 2019 surges. XEC, a recombinant of KS.1.1 and KP.3.3, contains T22N and F59S mutations in the spike protein's N-terminal domain (NTD). The T22N mutation, similar to the DelS31 mutation in KP.3.1.1, introduces a potential N-linked glycosylation site in XEC. In this study,...
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