Article

The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications

2025-04-07

Abstract excerpt

The XEC strain of SARS-CoV-2 has drawn particular attention because of its ability to outcompete existing Omicron strains. Defined by distinctive spike protein mutations, T22N and Q493E, XEC exhibits increased ACE2 binding affinity and partial immune evasion, which may compromise vaccine-induced neutralizing antibodies. Preliminary analyses also indicated that glycosylation changes at the N-terminal domain enhance...

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Literature Corpus work: 6c74e843-67c5-522a-9c19-0d42f57cb72a
DOI: 10.20944/preprints202504.0496.v1

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