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Article

Neutralization and spike stability of JN.1-derived LB.1, KP.2.3, KP.3, and KP.3.1.1 subvariants.

mBio - 14 May 2025

Li Pei, Faraone Julia N, Hsu Cheng Chih, Chamblee Michelle, Liu Yajie, Zheng Yi-Min, Xu Yan, Carlin Claire, Horowitz Jeffrey C, Mallampalli Rama K, Saif Linda J, Oltz Eugene M, Jones Daniel, Li Jianrong, Gumina Richard J, Bednash Joseph S, Xu Kai, Liu Shan-Lu

Abstract excerpt

During the summer of 2024, coronavirus disease 2019 (COVID-19) cases surged globally, driven by variants derived from JN.1 subvariants of severe acute respiratory syndrome coronavirus 2 that feature new mutations, particularly in the N-terminal domain (NTD) of the spike protein. In this study, we report on the neutralizing antibody (nAb) escape, infectivity, fusion, and spike stability of these subvariants-LB.1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40136024
DOI: 10.1128/mbio.00464-25
PMCID: PMC12077133

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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