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Article

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

25 Nov 2021

Abstract excerpt

BACKGROUND: Despite clinical success with anti-spike vaccines, the effectiveness of neutralizing antibodies and vaccines has been compromised by rapidly spreading SARS-CoV-2 variants. Viruses can hijack the glycosylation machinery of host cells to shield themselves from the host's immune response and attenuate antibody efficiency. However, it remains unclear if targeting glycosylation on viral spike protein can...

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PMID: 34839261
DOI: 10.1016/j.ebiom.2021.103712

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