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Article

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity.

Nature communications - 14 Dec 2025

Tsujino Shuhei, Tsuda Masumi, Deguchi Sayaka, Ito Jumpei, Taha Taha Y, Nasser Hesham, Wang Lei, Rosecrans Julia, Suzuki Rigel, Suzuki Saori, Yoshimatsu Kumiko, Ott Melanie, Ikeda Terumasa, Sato Kei, Takayama Kazuo, Tanaka Shinya, Tamura Tomokazu, Fukuhara Takasuke

Abstract excerpt

The global circulation of SARS-CoV-2 in human populations has driven the emergence of Omicron subvariants, which have become highly diversified through recombination. In late 2024, SARS-CoV-2 Omicron XEC variant emerged from the recombination of two JN.1 progeny, KS.1.1 and KP.3.3, and became predominant worldwide. Here, we investigate virological features of the XEC variant. Epidemic dynamics modeling suggests...

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Identifiers

PMID: 41392175
DOI: 10.1038/s41467-025-67455-4
PMCID: PMC12819382

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