Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men.

doi:10.1016/j.xhgg.2025.100428

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Article

Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men.

HGG advances - 10 Jul 2025

Janivara Rohini, Hazra Ujani, Pfennig Aaron, Harlemon Maxine, Kim Michelle S, Eaaswarkhanth Muthukrishnan, Chen Wenlong C, Ogunbiyi Adebola, Kachambwa Paidamoyo, Petersen Lindsay N, Jalloh Mohamed, Mensah James E, Adjei Andrew A, Adusei Ben, Joffe Maureen, Gueye Serigne M, Aisuodionoe-Shadrach Oseremen I, Fernandez Pedro W, Rohan Thomas E, Andrews Caroline, Rebbeck Timothy R, Adebiyi Akindele O, Agalliu Ilir, Lachance Joseph

Abstract excerpt

Androgenetic alopecia is a highly heritable trait. However, much of our understanding about the genetics of male-pattern baldness comes from individuals of European descent. Here, we examined a dataset comprising 2,136 men from Ghana, Nigeria, Senegal, and South Africa that were genotyped using the Men of African Descent and Carcinoma of the Prostate Array. We first tested how genetic predictions of baldness...

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PMID: 40134218
DOI: 10.1016/j.xhgg.2025.100428
PMCID: PMC12000746

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