Article
Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.
Nature communications - 8 Mar 2017
Heilmann-Heimbach Stefanie, Herold Christine, Hochfeld Lara M, Hillmer Axel M, Nyholt Dale R, Hecker Julian, Javed Asif, Chew Elaine G Y, Pechlivanis Sonali, Drichel Dmitriy, Heng Xiu Ting, Del Rosario Ricardo C-H, Fier Heide L, Paus Ralf, Rueedi Rico, Galesloot Tessel E, Moebus Susanne, Anhalt Thomas, Prabhakar Shyam, Li Rui, Kanoni Stavroula, Papanikolaou George, Kutalik Zoltán, Deloukas Panos, Philpott Michael P, Waeber Gérard, Spector Tim D, Vollenweider Peter, Kiemeney Lambertus A L M, Dedoussis George, Richards J Brent, Nothnagel Michael, Martin Nicholas G, Becker Tim, Hinds David A, Nöthen Markus M
Abstract excerpt
Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 × 10-8, METAL) of which 23 have not been reported previously. The 63 loci...
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