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Article

Enhanced diagnosis of multi-drug-resistant microbes using group association modeling and machine learning.

Nature communications - 25 Mar 2025

Saliba Julian G, Zheng Wenshu, Shu Qingbo, Li Liqiang, Wu Chi, Xie Yi, Lyon Christopher J, Qu Jiuxin, Huang Hairong, Ying Binwu, Hu Tony Ye

Abstract excerpt

New solutions are needed to detect genotype-phenotype associations involved in microbial drug resistance. Herein, we describe a Group Association Model (GAM) that accurately identifies genetic variants linked to drug resistance and mitigates false-positive cross-resistance artifacts without prior knowledge. GAM analysis of 7,179 Mycobacterium tuberculosis (Mtb) isolates identifies gene targets for all analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40133304
DOI: 10.1038/s41467-025-58214-6
PMCID: PMC11937555

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