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Article

Multivariable regression models improve accuracy and sensitive grading of antibiotic resistance mutations in Mycobacterium tuberculosis.

Nature communications - 4 Mar 2025

Kulkarni Sanjana G, Laurent Sacha, Miotto Paolo, Walker Timothy M, Chindelevitch Leonid, Nathanson Carl-Michael, Ismail Nazir, Rodwell Timothy C, Farhat Maha R

Abstract excerpt

Rapid genotype-based drug susceptibility testing for the Mycobacterium tuberculosis complex (MTBC) relies on a comprehensive knowledgebase of the genetic determinants of resistance. Here we present a catalogue of resistance-associated mutations using a regression-based approach and benchmark it against the 2nd edition of the World Health Organisation (WHO) mutation catalogue. We train multivariate logistic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40032816
DOI: 10.1038/s41467-025-57174-1
PMCID: PMC11876447

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