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Advantages of updated WHO mutation catalog combined with existing whole-genome sequencing-based approaches for Mycobacterium tuberculosis resistance prediction.

Genome medicine - 26 Mar 2025

Chen Yiwang, Zhang Xuecong, Liang Jialei, Jiang Qi, Peierdun Mijiti, Xu Peng, Takiff Howard E, Gao Qian

Abstract excerpt

BACKGROUND: The WHO recently released a second edition of the mutation catalog for predicting drug resistance in Mycobacterium tuberculosis (MTB). This study evaluated its effectiveness compared to existing whole-genome sequencing (WGS)-based prediction methods and proposes a novel approach for its optimization. METHODS: We tested the accuracy of five tools-the WHO catalog, TB Profiler, SAM-TB, GenTB, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40140944
DOI: 10.1186/s13073-025-01458-0
PMCID: PMC11938600

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