Article
Beyond multidrug resistance: Leveraging rare variants with machine and statistical learning models in Mycobacterium tuberculosis resistance prediction.
EBioMedicine - 1 May 2019
Chen Michael L, Doddi Akshith, Royer Jimmy, Freschi Luca, Schito Marco, Ezewudo Matthew, Kohane Isaac S, Beam Andrew, Farhat Maha
Abstract excerpt
BACKGROUND: The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susceptibility, but gaps remain for predicting phenotype accurately from genotypic data especially for certain drugs....
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