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Clusterin-mediated polarization of M2 macrophages: a mechanism of temozolomide resistance in glioblastoma stem cells

24 Mar 2025

Abstract excerpt

Glioblastoma remains one of the most lethal malignancies, largely due to its resistance to standard chemotherapy such as temozolomide. This study investigates a novel resistance mechanism involving glioblastoma stem cells (GSCs) and the polarization of M2-type macrophages, mediated by the extracellular vesicle (EV)-based transfer of Clusterin. Using 6-week-old male CD34 + humanized huHSC-(M-NSG) mice (NM-NSG-017)...

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PMID: 40128761
DOI: 10.1186/s13287-025-04247-z

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