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Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment

30 Jan 2025

Abstract excerpt

Background: Glioblastoma, associated with poor prognosis and impaired immune function, shows potential interactions between newly identified disulfidptosis mechanisms and T cell exhaustion, yet these remain understudied. Methods: Key genes were identified using Lasso regression, followed by multivariate analysis to develop a prognostic model. Single-cell pseudotemporal analysis explored disulfidptosis T-cell...

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PMID: 39949776
DOI: 10.3389/fimmu.2025.1526296

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