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Article

Glioma-derived small extracellular vesicles induce pericyte-phenotype transition of glioma stem cells under hypoxic conditions.

Cellular signalling - 1 Sept 2023

Cheng Yue, Li Shijie, Hou Yongying, Wan Weijun, Wang Ke, Fu Shihui, Yuan Ye, Yang Kaidi, Ye Xiufeng

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is the most common and lethal primary brain tumor characterized by extensive vascularization. Anti-angiogenic therapy for this cancer offers the possibility of universal efficacy. However, preclinical and clinical studies suggest that anti-VEGF drugs, such as Bevacizumab, actively promote tumor invasion, which ultimately leads to a therapy-resistant and recurrent phenotype of GBMs....

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Identifiers

PMID: 37315748
DOI: 10.1016/j.cellsig.2023.110754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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