Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality

21 Jul 2021

Abstract excerpt

A robust monoclonal antibody (mAb) bioprocess requires physiological parameters such as temperature, pH, or dissolved oxygen to be well-controlled as even small variations in them could potentially impact the final product quality. For instance, pH substantially affects N-glycosylation, protein aggregation, and charge variant profiles, as well as mAb productivity. However, relatively less is known about how pH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Monoclonal and Polyclonal Antibodies Research
Share to Protein purification and stability
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34289087
DOI: 10.1002/bit.27899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product qualityPMID 34289087Read ↗

Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process developmentSemantic proximity Read ↗

Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO CellsSemantic proximity Read ↗

A multi‐pronged investigation into the effect of glucose starvation and culture duration on fed‐batch CHO cell cultureSemantic proximity Read ↗

pH excursions impact CHO cell culture performance and antibody N-linked glycosylationSemantic proximity Read ↗

Beyond viability: Advancing CHO cell culture process strategies to modulate host cell protein levelsSemantic proximity Read ↗

High-Antibody-Producing Chinese Hamster Ovary Cells Up-Regulate Intracellular Protein Transport and Glutathione SynthesisSemantic proximity Read ↗

Multi-omics profiling of CHO parental hosts reveals cell line-specific variations in bioprocessing traitsSemantic proximity Read ↗

Impact of cell culture on recombinant monoclonal antibody product heterogeneitySemantic proximity Read ↗

Proteomics Reveals Distinctive Host Cell Protein Expression Patterns in Fed‐Batch and Perfusion Cell Culture ProcessesSemantic proximity Read ↗

Modulation of mAb quality attributes using microliter scale fed‐batch culturesSemantic proximity Read ↗

A reflection on the improvement of Chinese hamster ovary cell-based bioprocesses through advances in proteomic techniques.Semantic proximity Read ↗

Effect of different cell culture media on the production and glycosylation of a monoclonal antibody from a CHO cell lineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.