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Article

Modulation of mAb quality attributes using microliter scale fed‐batch cultures

28 Apr 2014

Abstract excerpt

A high-throughput DoE approach performed in a 96-deepwell plate system was used to explore the impact of media and feed components on main quality attributes of a monoclonal antibody. Six CHO-S derived clonal cell lines expressing the same monoclonal antibody were tested in two different cell culture media with six components added at three different levels. The resulting 384 culture conditions including controls...

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PMID: 24777991
DOI: 10.1002/btpr.1921

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