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Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation

22 Mar 2025

Abstract excerpt

Non-energetic roles for glucose are largely unclear, as is the interplay between transcription factors (TFs) and ubiquitous biomolecules. Metabolomic analyses uncovered elevation of intracellular glucose during differentiation of diverse cell types. Human and mouse tissue engineered with glucose sensors detected a glucose gradient that peaked in the outermost differentiated layers of the epidermis. Free glucose...

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PMID: 40120584
DOI: 10.1016/j.stem.2025.02.017

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