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Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states

28 Oct 2020

Abstract excerpt

The interfollicular epidermis (IFE) forms a water-tight barrier that is often disrupted in inflammatory skin diseases. During homeostasis, the IFE is replenished by stem cells in the basal layer that differentiate as they migrate toward the skin surface. Conventionally, IFE differentiation is thought to be stepwise as reflected in sharp boundaries between its basal, spinous, granular and cornified layers. The...

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PMID: 33116143
DOI: 10.1038/s41467-020-19234-6

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