Article
Characterization of an inherited HLA-B gene deletion in a candidate for hematopoietic cell transplantation.
Human immunology - 1 May 2026
Chi Liying, Blackburn Patrick R, Siskar Alexa N, Wirtz Carla, Edwards Jessica, Bullard Krystal, Beck Christie, Arnold Paula Y
Abstract excerpt
Accurate high-resolution genotyping of HLA genes for hematopoietic cell transplant (HCT) recipients provides critical information for matching and donor selection. We describe unusual family typing for a pediatric transplant candidate which revealed that the patient and mother did not share a common HLA-B allele, although all other class I and class II HLA alleles inherited on the maternal haplotype were...
Topics
- Humans
- Hematopoietic Stem Cell Transplantation
- HLA-B Antigens
- Female
- Gene Deletion
- Haplotypes
- Alleles
- High-Throughput Nucleotide Sequencing
- Histocompatibility Testing
- Pedigree