Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of the HLA-B Gene in One of the Inherited Haplotypes in a Northern European Family.

HLA - 1 May 2025

Grünebach Frank, Haack Tobias B, Döring Michaela, Merz Britta, Petz Antje, Bauer Christine, Storz Martina, Lang Peter, Klein Reinhild

Abstract excerpt

Targeted next generation sequencing-based HLA typing of a 17-year-old female transplant patient showed homozygosity for the HLA-B allele. The segregation analysis of HLA haplotypes of family members only allowed the conclusion that the B-allele was deleted in the haplotype inherited from the father and accordingly paternal grandfather, resulting in false homozygous genotyping. The subsequent whole-genome...

Read the complete abstract on PubMed

Topics

Adolescent
Female
Humans
Male
Alleles
Haplotypes
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Histocompatibility Testing

HLA-B Antigens

Homozygote

Pedigree

Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 40345160
DOI: 10.1111/tan.70234
PMCID: PMC12062917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of the HLA-B Gene in One of the Inherited Haplotypes in a Northern European Family.PMID 40345160Read ↗

Characterization of an inherited HLA-B gene deletion in a candidate for hematopoietic cell transplantation.Semantic proximity Read ↗

Four Novel Intronic Variants of HLA-B Identified by Next-Generation Sequencing.Semantic proximity Read ↗

The Case of a Missing HLA-B Gene.Semantic proximity Read ↗

[Genetic analysis of a Chinese pedigree with an allele dropout at the HLA-B locus].Semantic proximity Read ↗

The complete genomic sequence of HLA-DRB1*10:01:01 was identified by sequencing in a Han Chinese individual.Semantic proximity Read ↗

Filling the gaps - the generation of full genomic sequences for 15 common and well-documented HLA class I alleles using next-generation sequencing technology.Semantic proximity Read ↗

A novel HLA-A*0119 allele of a Caucasian family containing a mutation in a highly conserved region.Semantic proximity Read ↗

Cloning and sequencing full-length HLA-B and -C genes.Semantic proximity Read ↗

Uncommon HLA alleles identified by hemizygous ultra-high Sanger sequencing: haplotype associations and reconsideration of their assignment in the Common and Well-Documented catalogue.Semantic proximity Read ↗

DNA sequencing-based HLA typing detects a B-cell ALL blast-specific mutation in HLA-A(*)2402 resulting in loss of HLA allele expression.Semantic proximity Read ↗

HLA-DR Haplotype Diversity Revealed by Pangenome Sequence Analysis.Semantic proximity Read ↗

Full-length extension of HLA allele sequences by HLA allele-specific hemizygous Sanger sequencing (SSBT).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.