Article
Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension.
Current hypertension reports - 1 Dec 2011
Wang Xiaoling, Prins Bram P, Sõber Siim, Laan Maris, Snieder Harold
Abstract excerpt
Genetic linkage and association methods have long been the most important tools for gene identification in humans. These approaches can either be hypothesis-based (i.e., candidate-gene studies) or hypothesis-free (i.e., genome-wide studies). The first part of this review offers an overview of the latest successes in gene finding for blood pressure (BP) and essential hypertension using these DNA sequence-based...
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