Integration of single-nuclei and spatial transcriptomics to decipher tumor phenotype predictive of relapse-free survival in Wilms tumor.

doi:10.3389/fimmu.2025.1539897

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Article

Integration of single-nuclei and spatial transcriptomics to decipher tumor phenotype predictive of relapse-free survival in Wilms tumor.

Frontiers in immunology - 1 Jan 2025

Yang Ran, Xie Lulu, Wang Rui, Li Yi, Lu Yifei, Liu Baihui, Dai Shuyang, Zheng Shan, Dong Kuiran, Dong Rui

Abstract excerpt

Background: Wilms tumor (WT) is the most common childhood renal malignancy, with recurrence linked to poor prognosis. Identifying the molecular features of tumor phenotypes that drive recurrence and discovering novel targets are crucial for improving treatment strategies and enhancing patient outcomes. Methods: Single-nuclei RNA sequencing (snRNA-seq), spatial transcriptomics (ST), bulk RNA-seq, and mutation/copy...

Read the complete abstract on PubMed

Topics

Humans
Wilms Tumor
Transcriptome
Kidney Neoplasms
Prognosis
Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Gene Expression Profiling

Machine Learning

Male

Female

Single-Cell Analysis

Gene Expression Regulation, Neoplastic

Source

Open in PubMed Open full text

Identifiers

PMID: 40098972
DOI: 10.3389/fimmu.2025.1539897
PMCID: PMC11911335

Genes

EGFR
TGFA

Provenance

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