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Article

Single-cell transcriptomic analysis reveals the immune landscape of lung in steroid-resistant asthma exacerbation

4 Jan 2021

Abstract excerpt

Significance Asthma exacerbation is not prevented by standard corticosteroid-based therapy and is the major burden in terms of morbidity, mortality, and health care costs associated with asthma. Etiology of disease exacerbation is highly heterogeneous. Using single-cell RNA deep sequencing, we undertook a large-scale, high-dimensional analysis of the immune landscape in lung following dexamethasone treatments in...

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PMID: 33397719
DOI: 10.1073/pnas.2005590118

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