Implications of EGFR expression on EGFR signaling dependency and adaptive immunity against EGFR-mutated lung adenocarcinoma.

doi:10.1016/j.lungcan.2025.108494

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Article

Implications of EGFR expression on EGFR signaling dependency and adaptive immunity against EGFR-mutated lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2025

Torasawa Masahiro, Yoshida Tatsuya, Shiraishi Kouya, Yagishita Shigehiro, Ono Hanako, Uehara Yuji, Miyakoshi Jun, Tateishi Akiko, Igawa Yukiko Shimoda, Higashiyama Ryoko Inaba, Mochizuki Akifumi, Masuda Ken, Matsumoto Yuji, Shinno Yuki, Okuma Yusuke, Goto Yasushi, Horinouchi Hidehito, Hamamoto Ryuji, Yamamoto Noboru, Watanabe Shun-Ichi, Yatabe Yasushi, Takahashi Kazuhisa, Kohno Takashi, Ohe Yuichiro

Abstract excerpt

BACKGROUND: In EGFR-mutated lung adenocarcinoma (EGFRm LUAD), EGFR mutations do not necessarily result in increased EGFR expression (EGFR-exp), which differs among patients. However, the factors influencing EGFR-exp and the impact of EGFR-exp on tumor characteristics in patients with EGFRm LUAD remain unclear. PATIENTS AND METHODS: Whole-exome and RNA sequencing were performed for patients with early- and...

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Topics

Humans
ErbB Receptors
Adenocarcinoma of Lung
Lung Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Male

Female

Tumor Microenvironment

Signal Transduction

Middle Aged

Aged

Adaptive Immunity

Retrospective Studies

Prognosis

Source

Open in PubMed

Identifiers

PMID: 40088580
DOI: 10.1016/j.lungcan.2025.108494

Genes

EGFR
TP53

Provenance

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