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Article

Myeloid-Derived Growth Factor-Regulated Oncogenesis in Lung Adenocarcinoma Is Associated with EGFR Status and Cancer Aggressiveness.

Journal of proteome research - 5 Sept 2025

Hsiao Ting-Feng, Wang Chih-Liang, Wu Yi-Cheng, Kuo Chia-Yu, Lin Ke-Wei, Chuang Wen-Yu, Yeh Chi-Ju, Wu Chia-Chun, Liu Ko-Jiunn, Chang Gee-Chen, Chien Kun-Yi, Yu Jau-Song, Yu Chia-Jung

Abstract excerpt

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have transformed lung adenocarcinoma (LUAD) treatment in EGFR-mutant (MT) patients, but strategies targeting wild-type (WT) EGFR tumors remain necessary. This study analyzed a diverse LUAD patient cohort with EGFR mutation statuses and wild-type profiles for ALK and KRAS to identify stage-specific biomarkers. Using quantitative proteomics and...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40752010
DOI: 10.1021/acs.jproteome.5c00385
PMCID: PMC12419241

Genes

EGFR
MYDGF
ALK
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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