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Exploring the Cause of Survival Disparities in EGFR-mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes

2023-09-12

Abstract excerpt

Differences in the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been observed between lung cancer patients with 19 exon deletion (19Del) and L858R mutation. We investigate the multi-omics information from the TCGA LUAD dataset and validate it using the GEO (GSE190139, GSE147377) and MSK datasets. Somatic loss-of-function alteration of RBM10 and altered Immune infiltration...

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Literature Corpus work
215092b8-3f14-5f65-b12e-1f56d9afd86e
DOI
10.21203/rs.3.rs-3332742/v1
Open publication

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Exploring the Cause of Survival Disparities in EGFR-mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation SubtypesDOI 10.21203/rs.3.rs-3332742/v1
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