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Consideration of a Liquid Mutation-Accumulation Experiment to Measure Mutation Rates by Successive Serial Dilution.

Genome biology and evolution - 3 Apr 2025

Baehr Stephan, Ho Wei-Chin, Perez Samuel, Cenzano Alyssa, Hancock Katelyn, Patrick Lea, Brown Adalyn, Miller Samuel, Lynch Michael

Abstract excerpt

The mutation-accumulation (MA) experiment is a fixture of evolutionary biology, though its execution is laborious. MA experiments typically take between months and years to acquire sufficient mutations to measure DNA mutation rates and mutation spectra. MA experiments for many organisms rely on colony formation on agar plates and repetitive streaking, an environment which at first glance appears somewhat...

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PMID: 40088461
DOI: 10.1093/gbe/evaf049
PMCID: PMC11973482

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