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Article

Single-cell and spatial transcriptomics approaches of the bone marrow microenvironment

13 Dec 2019

Abstract excerpt

PURPOSE OF REVIEW: The bone marrow is home to hematopoietic stem cells responsible for lifelong blood production, alongside mesenchymal stem cells required for skeletal regeneration. In the bone marrow, a unique combination of signals derived from a multitude of cell types results in the establishment of so-called niches that regulate stem-cell maintenance and differentiation. Recently, single-cell and spatially...

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PMID: 31833957
DOI: 10.1097/cco.0000000000000602

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