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Article

Sequence Diversity in the 3' Untranslated Region of Alphavirus Modulates IFIT2-Dependent Restriction in a Cell Type-Dependent Manner.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Apr 2025

Hickson Sarah E, Brekke Eden, Schwerk Johannes, Saluhke Indraneel, Zaver Shivam, Woodward Joshua, Savan Ram, Hyde Jennifer L

Abstract excerpt

Alphaviruses (family Togaviridae) are a diverse group of positive-sense RNA (+ssRNA) viruses that are transmitted by arthropods and are the causative agent of several significant human and veterinary diseases. Interferon (IFN)-induced proteins with tetratricopeptide repeats (IFITs) are a family of RNA-binding IFN-stimulated genes (ISGs) that are highly upregulated following viral infection and have been...

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Identifiers

PMID: 40079162
DOI: 10.1089/jir.2024.0229
PMCID: PMC12491954

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