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Article

Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus.

Virology - 1 Sept 2016

Bhalla Nishank, Sun Chengqun, Metthew Lam L K, Gardner Christina L, Ryman Kate D, Klimstra William B

Abstract excerpt

Most previous studies of interferon-alpha/beta (IFN-α/β) response antagonism by alphaviruses have focused upon interruption of IFN-α/β induction and/or receptor signaling cascades. Infection of mice with Venezuelan equine encephalitis alphavirus (VEEV) or Sindbis virus (SINV) induces serum IFN-α/β, that elicits a systemic antiviral state in uninfected cells successfully controlling SINV but not VEEV replication....

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Identifiers

PMID: 27318152
DOI: 10.1016/j.virol.2016.06.005
PMCID: PMC5821108

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