Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome.

doi:10.1038/s41467-020-17596-5

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Article

Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome.

Nature communications - 7 Aug 2020

Capaci Valeria, Bascetta Lorenzo, Fantuz Marco, Beznoussenko Galina V, Sommaggio Roberta, Cancila Valeria, Bisso Andrea, Campaner Elena, Mironov Alexander A, Wiśniewski Jacek R, Ulloa Severino Luisa, Scaini Denis, Bossi Fleur, Lees Jodi, Alon Noa, Brunga Ledia, Malkin David, Piazza Silvano, Collavin Licio, Rosato Antonio, Bicciato Silvio, Tripodo Claudio, Mantovani Fiamma, Del Sal Giannino

Abstract excerpt

TP53 missense mutations leading to the expression of mutant p53 oncoproteins are frequent driver events during tumorigenesis. p53 mutants promote tumor growth, metastasis and chemoresistance by affecting fundamental cellular pathways and functions. Here, we demonstrate that p53 mutants modify structure and function of the Golgi apparatus, culminating in the increased release of a pro-malignant secretome by tumor...

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Identifiers

PMID: 32770028
DOI: 10.1038/s41467-020-17596-5
PMCID: PMC7414119

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