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Article

ELK1/NOL3/GRP78 axis regulates proliferation and stemness in TP53-mutant colon cancer by enhancing adaptive endoplasmic reticulum stress.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2026

Zhang Lifen, Gao Yang, Xu Jingjing, Ye Jiahao, Wen Youle, Li Tian, He Weiling

Abstract excerpt

BACKGROUND: Colon cancer harboring TP53 mutations is highly aggressive and associated with short survival. Adaptive, rather than apoptotic, endoplasmic reticulum (ER) stress endows TP53-mutant tumor cells with enhanced protein-folding capacity, metabolic plasticity, and chemoresistance. However, the upstream regulators that selectively drive this cytoprotective program within the cancer stem cell compartment...

Topics

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Colonic Neoplasms
Endoplasmic Reticulum Chaperone BiP
Endoplasmic Reticulum Stress
Gene Expression Regulation, Neoplastic
HCT116 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heat-Shock Proteins

Neoplastic Stem Cells

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 41864308
DOI: 10.1016/j.bbadis.2026.168227

Genes

TP53
NOL3
ELK1
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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