Article
Feedback-resistant acetohydroxy acid synthase increases valine production in Corynebacterium glutamicum.
Applied and environmental microbiology - 1 Jan 2005
Elisáková Veronika, Pátek Miroslav, Holátko Jirí, Nesvera Jan, Leyval Damien, Goergen Jean-Louis, Delaunay Stéphane
Abstract excerpt
Acetohydroxy acid synthase (AHAS), which catalyzes the key reactions in the biosynthesis pathways of branched-chain amino acids (valine, isoleucine, and leucine), is regulated by the end products of these pathways. The whole Corynebacterium glutamicum ilvBNC operon, coding for acetohydroxy acid s...
Topics
- Acetolactate Synthase
- Amino Acid Sequence
- Amino Acids, Branched-Chain
- Bacterial Proteins
- Corynebacterium glutamicum
- Gene Expression Regulation, Bacterial
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Operon
- Plasmids
- Valine